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Mechanistically, it activates the Nrf2 cytoprotective system by promoting Keap1 degradation via Atg7-dependent autophagy, disrupting the Keap1-Nrf2 interaction and enhancing Nrf2 nuclear translocation (260)

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The primary role of GSTs is to detoxify xenobiotics by catalyzing the nucleophilic attack by GSH on electrophilic carbon, sulfur, or nitrogen atoms of said nonpolar xenobiotic substrates, thereby preventing their interaction with crucial cellular proteins and nucleic acids

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Drug: Nitroglycerin- is typically taken sublingually (buccal cavity) where it enters the circulation and is rapidly delivered directly to the heart (without having to go through the liver first), thus avoiding the First Pass Effect